Advancing risk assessment science

Human health (continued)

BREAK-OUT SESSION

Thursday 20 September 2018 / 08:30 - 12:15

The National Academies of Sciences, Engineering, and Medicine recently published a report that provides considerations and recommendations on how the latest scientific and technological advances in toxicology, exposure science and epidemiology could be integrated and used to further advance risk assessments. New tools are emerging that enable a better understanding of adverse effects at the molecular level, and more accurate predictions of biological responses. Most of these tools will be non-animal testing models. Moreover, epidemiological research is facing a transition from empirical observations alone to the provision of information on the pathogenesis. These developments are promising for the improvement of human health risk assessments as well as the reduction of animal testing.

This session will highlight relevant advances, unresolved challenges, and needs for human health risk assessment. The usefulness of the traditional risk assessment paradigm (hazard characterisation, exposure assessment and risk characterisation) will be addressed holistically, accounting for the challenges that a paradigm shift may entail. New tools that may facilitate this transition will be discussed.

 

Chair
Angelika Tritscher World Health Organization
Chair
Heather Wallace University of Aberdeen
08:30-09:00

CLARITY-BPA Project: Core NCTR/NTP study on BPA

Barry Delclos

US Food & Drug Administration
09:00-09:30

Integrating regulatory and academic investigations in hazard assessments by the US National Toxicology Program. Lessons learned from the CLARITY-BPA initiative

Nigel Walker

National Institute of Environmental Health Sciences
09:30-10:00

Use of epidemiological studies for setting a health-based guidance value

Thorhallur I Halldorsson

University of Iceland
10:00-10:30 Coffee break
10:30-10:55

The potential impact of toxicogenomics on modern chemical risk assessment – 3-MCPD as example

Alfonso Lampen

Federal Institute for Risk Assessment
10:55-11:20

Use of modelisation tools to assess risks related to cadmium exposure for workers and consumers

Christophe Rousselle

French Agency for Food, Environmental and Occupational Health & Safety
11:20-12:15

Moderated Panel discussion

Moderator: Maged Younes

European Food Safety Authority’s Panel on Food Additives and Nutrient Sources Added to Food

Moderator: Ellen Fritsche

Leibniz Research Institute for Environmental Medicine

 

Panellists

Susanne Hougaard Bennekou

Danish Environmental Protection Agency

Daniel Doerge

US Food & Drug Administration

Thorhallur I Halldorsson

University of Iceland

Marcel Leist

University of Kostanz

Ellen Mantus

US National Academies of Sciences, Engineering and Medicine

Maurice Whelan

Joint Research Centre
12:15-13:45 Lunch and poster exhibit

rapporteurs

Anna Federica Castoldi European Food Safety Authority
George Kass European Food Safety Authority
Anna Lanzoni European Food Safety Authority
Andrea Terron European Food Safety Authority

Full programme