Advancing risk assessment science

Human health

BREAK-OUT SESSION

Wednesday 19 September 2018 / 08:30 - 17:30

The National Academies of Sciences, Engineering, and Medicine recently published a report that provides considerations and recommendations on how the latest scientific and technological advances in toxicology, exposure science and epidemiology could be integrated and used to further advance risk assessments. New tools are emerging that enable a better understanding of adverse effects at the molecular level, and more accurate predictions of biological responses. Most of these tools will be non-animal testing models. Moreover, epidemiological research is facing a transition from empirical observations alone to the provision of information on the pathogenesis. These developments are promising for the improvement of human health risk assessments as well as the reduction of animal testing.

This session will highlight relevant advances, unresolved challenges, and needs for human health risk assessment. The usefulness of the traditional risk assessment paradigm (hazard characterisation, exposure assessment and risk characterisation) will be addressed holistically, accounting for the challenges that a paradigm shift may entail. New tools that may facilitate this transition will be discussed.

 

Chair
Guilhem De Seze European Food Safety Authority
Chair
Maurice Whelan Joint Research Centre
08:30-08:35

Opening of session and welcome

Maurice Whelan

Joint Research Centre
08:35-09:05

How simple heuristics influence laypeople’s risk perception

Michael Siegrist

ETH Zürich
09:05-09:35

Using 21st century science to improve risk assessment: Opportunities and challenges

Ellen Mantus

US National Academies of Sciences, Engineering and Medicine
09:35-10:00

Holistic approach to human health risk assessment – Is the current approach fit for purpose?

Susanne Hougaard Bennekou

Danish Environmental Protection Agency
10:00-10:30 Coffee break
10:30-10:55

Use of epidemiological studies for chemical risk assessment: How to take advantage of their strengths and deal with their limitations?

Thorhallur I Halldorsson

University of Iceland
10:55-11:20

New approach methods (NAM) in toxicology for mechanism-based hazard assessment

Marcel Leist

University of Kostanz
11:20-12:15

Moderated Panel discussion

Moderator: Maged Younes

European Food Safety Authority’s Panel on Food Additives and Nutrient Sources Added to Food

Panellists

Susanne Hougaard Bennekou

Danish Environmental Protection Agency

Thorhallur I Halldorsson

University of Iceland

Marcel Leist

University of Kostanz

Ellen Mantus

US National Academies of Sciences, Engineering and Medicine

Michael Siegrist

ETH Zürich
12:15-13:45 Lunch and poster exhibit
Chair
Angelika Tritscher World Health Organization
Chair
Heather Wallace University of Aberdeen
13:45-14:05

Human biomonitoring: The European Joint Programme HBM4EU

Marike Kolossa

German Environment Agency
14:05-14:25

Internal dosimetrics enable holistic assessment of exposures to environmental and endogenous estrogens

Daniel Doerge

US Food & Drug Administration
14:25-14:45

Integrating pharmacokinetics and pharmacodynamics in AOPs for next generation risk assessments

Frédéric Bois

French National Institute for Industrial Environment and Risks
14:45-15:05

The exposome in practice

Paolo Vineis

Imperial College
15:05-15:15

Questions and answers

Heather Wallace

University of Aberdeen

Angelika Tritscher

World Health Organization

 

15:15-15:45 Coffee break
15:45-16:05

EU-ToxRisk: Towards new chemical safety testing strategies using new approach methods

Robert van de Water

Leiden University
16:05-16:25

Assessment of chemical mixture-induced developmental neurotoxicity using human in vitro model

Anna Price

Joint Research Centre
16:25-16:45

Assessing the safety of genetically modified food/feed: The GRACE and G-TwYST experience

Pablo Steinberg

Federal Research Institute of Nutrition and Food
16:45-17:05

Predictive tools in the risk assessment of new proteins in GMOs: The case of celiac disease

Frits Koning

Leiden University Medical Center
17:05-17:15

Questions and answers

Heather Wallace

University of Aberdeen

Angelika Tritscher

World Health Organization

 

17:15-17:30

Wrap up – Concluding remarks

Maged Younes

European Food Safety Authority’s Panel on Food Additives and Nutrient Sources Added to Food

Ellen Fritsche

Leibniz Research Institute for Environmental Medicine

 

17:30-18:00 Poster exhibit and poster pitches

rapporteurs

Anna Federica Castoldi European Food Safety Authority
George Kass European Food Safety Authority
Anna Lanzoni European Food Safety Authority
Andrea Terron European Food Safety Authority

Full programme